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butthole 

A flesh hold that excretes feces and in some cases cum or a type of cream if something long hard thick juicy black slightly curved to the left is inserted and can be eaten out .
A butthole is a flesh hole.
butthole by anonymous May 19, 2023

Butthole 

An anus.
Hey does this thing on my butthole look infected to you?
Butthole by NapoleonD January 5, 2024

Butthole 

Between dem cheeks
Butthole by Lover9797 April 10, 2024

Butthole 

When a 5 year old is not allowed to say the word “ass” in asshole but in reality makes it 1 googolplex times worse.
Kid: You are such a butthole!
Dude: dies
Butthole by 147852369/*-+.0 August 12, 2025

Butthole Cancer 

Butthole Cancer is another way of referring to anal cancer. Anal cancer is a type of cancer that occurs in the anal canal and the anus. It is a rare disease among the general population, but is very common among gay men. Along with that, infections like HIV and Syphilis are also very common among gay men.

Gay men who don’t have HIV are over 20 times more likely to get anal cancer than the general population. Gay men who DO have HIV are about 100 times more likely to get anal cancer. Rates of anal cancer among gay men have been increasing every year.

This is because gay sex often causes anal fissures or tears. The anus is supposed to remove waste from the body, and having gay sex will eventually cause tears and cuts to the anus. These tears can get infected.
If you're a gay man, then your chances of getting infections and diseases like HIV, AIDS, Syphilis, and anal cancer (or butthole cancer) are quite high.
Butthole Cancer by Medical School October 18, 2019

butthole malfunction 

An involuntary bowel movement usually caused by questionable food choices.
Ugh man, what's that smell?!
I just had a butthole malfunction courtesy of Taco Bell!
butthole malfunction by Gleen707 November 28, 2019