Top definition
Butthole Cancer is another way of referring to anal cancer. Anal cancer is a type of cancer that occurs in the anal canal and the anus. It is a rare disease among the general population, but is very common among gay men. Along with that, infections like HIV and Syphilis are also very common among gay men.

Gay men who don’t have HIV are over 20 times more likely to get anal cancer than the general population. Gay men who DO have HIV are about 100 times more likely to get anal cancer. Rates of anal cancer among gay men have been increasing every year.

This is because gay sex often causes anal fissures or tears. The anus is supposed to remove waste from the body, and having gay sex will eventually cause tears and cuts to the anus. These tears can get infected.
If you're a gay man, then your chances of getting infections and diseases like HIV, AIDS, Syphilis, and anal cancer (or butthole cancer) are quite high.
via giphy
by Medical School October 18, 2019
Get the mug
Get a Butthole Cancer mug for your bunkmate Trump.
2
A less serious name for anal and/or colon cancer
Dr. Gupta: You have butthole cancer.

Mr. Larrity: What are you talking about?

Dr. Gupta: It affects 99% of CEOs and 100% of politicians at some point in their lives. We will have to remove your butthole before it spreads.
by ThomasGRogan November 26, 2009
Get the mug
Get a butthole cancer mug for your Aunt Larisa.
3
a more humorous form of colon cancer
johhny: dude, my gerbil just died. doc says its from colon cancer.
Johnny: wtf? how did he get butthole cancer?
by tallywacker June 10, 2008
Get the mug
Get a butthole cancer mug for your cat Paul.