by Lancey Vuongstein June 18, 2005

a person that is very close to you and you love like a sister. you tell them everything and are best friends. you are almost always with each other. sista frans are BEYOND just friends
Shea: is that girl Katie your friend?
Carly: She's not only my friend, she's my sista fran
or
Katie: hey sista fran, what's up?
Carly: nothing much, wanna hang out. go shopping or something?
Carly: She's not only my friend, she's my sista fran
or
Katie: hey sista fran, what's up?
Carly: nothing much, wanna hang out. go shopping or something?
by runnergirl365 February 24, 2011

by Wakantank May 16, 2008

A man who talks and talks and talks, regardless of who is listening (or not listening). The origins of the word are derived from the word "man" and "fran drescher" (the actress who played the talkative nanny on the hit show "The Nanny".
Tom: You get your work done today ??
Bob: Hell no....man-fran popped by and wouldn't leave. He just kept talking and talking.
Bob: Hell no....man-fran popped by and wouldn't leave. He just kept talking and talking.
by manfran October 16, 2008

Francesca and I have been friends for months and when I asked her on a date, she totally Fran zoned me!!
by punpunpun December 1, 2018

by ErosK January 15, 2021

When a female in a friend group predominantly occupied by males is packing the most heat. Someone with Fran's Cock is usually at least 12 inches long.
by Joebrook March 3, 2022
