2S 

2S means two-spirit.
Two-spirit people (also two spirit or twospirit) is a modern umbrella term used by some indigenous North Americans for gender variant individuals in their communities. Non-Native anthropologists have historically used the term berdaches for individuals who fulfill one of many mixed gender roles in First Nations and Native American tribes, but this term has more recently fallen out of favour.

"Are you a boy or a girl?"
"I'm two-spirit or 2S."

2S by monkeyface4568 March 20, 2015

2s and fews 

Getting money up

I gotta get my 2s and fews up

2s and fews by Convirtyou November 30, 2021

2s up 

When you throw twos up there’s really not much too it. You’re a real ass nigga.

Guy one: Yo you see him throwing 2s up??
Guy two: Yea! He’s a real ass Nigga!

2s up by enelicio May 1, 2023

1s and 2s 

1s and 2s are turntables(or decks)which have been the weapon of choice for djs such as dj premier of the xecutioners, mixmaster mike,dj babu of dialated peoples, and many more.....

hey man u cumin the club my boi is on the 1s and 2s tonight

1s and 2s by james Mc T January 3, 2009

Plus Twos (Plus 2s)  

Plus Twos (2s) are the slang name for breast implants. The term “Plus Two (2s)” has 2 meanings, 1) the implants usually result in an increase of 2 cup sizes, 2) the women who receive Plus 2s technically and typically though not always, would be rated by their male counter parts as being 2 points higher on the proverbial 1 to 10 scale.

Dude, I saw Tara at the club on Friday, she dropped 10 pounds and got a set of Plus Twos (Plus 2s) now she is a 7 instead of a 5 and I would do her after a 6 pack.

My boyfriend dumped me for a chick with Plus Twos (Plus 2s) I think it may be time to make an appointment for a set.

Plus Twos (Plus 2s) by DTM92663 May 29, 2008

2 2s 

2 2s
A Toronto way of saying honestly

Yo 2 2s your cheesing me fam, come off my line

Yo 2 2s that baddie has a fat ass

2 2s by RexCorvus100 July 2, 2019

Throwing up 2s

Your a real nigga who gets pape tries to stay out the mix and is not a bitch and will kill anyone who tries em.

When you are throwing up 2s you make the bitches wet

Throwing up 2s by W stuff gangy May 22, 2022