Bigbrain Share definition Flag 1: Someone with a brain so f-en big, it literally makes them more dumb than smart. 2: a dumb ass nerd I have I bigbrain and you have a small ass brain like a hamster eating a horse butt. Bigbrain by DankChez October 7, 2019 0 0 Get merch Get the Bigbrain mug. Buy Now — $32.95 See more merch