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A meme-level expression used in response to anything sexually pleasing/enticing, whether it is an image, video, song, or written content.

It is most commonly used as a simple image macro featuring George Takei; the meme itself probably originated from instances of Takei saying "Oh, my!" in response to sexy stuff, especially on the Howard Stern show.
Howard Stern: Hey Jonah, let's see that gigantic penis of yours.
Jonah Falcon: K. *whips out 13-incher.*
George Takei: Oh my! :
Oh My by Dr. Dick Delaware September 19, 2012
When you have your back to your partner and you reach around to touch his penis for the first time. Then you realize it’s huge and scream oh my. This is considered a mom moment.
“Oh my! I have never felt anything that big in my life
Oh my by Samala May 28, 2018
'Oh my...ankle'
oh my by DeeDub November 4, 2003
A term used in response to sexual behaviors, or suggestion. The person who says the term does it with much feeling, to help the person who spoke to them, to him/her to leave them alone.
John: Yeah, I just can't wait to eat you out !
Carrie: Oh My!
Oh My by P3DR0 June 6, 2007
when you are going to drink you call it oh my
hey are we gonna oh my at jons house tonight
oh my by taylor June 15, 2003
you say this when you are asking about whats going on this weekend (party wise).
hey guys...Oh my???
oh my by bob June 5, 2003