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A dope, idiot, dummy. It's used not so much as a deep condemnation of character, as commentary of an incident or discrete act. And, meant to disparage the person at that moment for what occurred.

I appreciate that on yahoo it was noted that it's necessarily a mean thing to say

also dufus..........dufəs
I am such a dufuss. Every year I forget my Irish Aunt Trish's birthday, and have to ask my mother-in-law if it's exactly on St Patrick's day.

Happy birthday Trish
dufuss by grubecnerwal July 22, 2016
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Dufus Moronicus 

the combination of a dufus and a moron
"Bart, you're not just a dufus, you're a dufus moronicus."
Dufus Moronicus by chitsb January 9, 2009
Related Words
Your acting like a big dufus .
Dufus by friskychick September 3, 2016
William Dafoe’s crotch or bussy.
Ive had many hot nights thinking about Dafussy.
Dafussy by fluttertits January 3, 2022

Hipster Dufus 

A word whose origins come from the hit television sitcom "Seinfeld". One of the recurring characters, Cosmo Kramer, had been called this (as far as I know, on more than one occasion).

I assume it's supposed to be an insult, referring to the person as someone who thinks they're cool, yet is (according to the insulter) quite the opposite.
"Am I a hipster dufus, Jerry?"
Hipster Dufus by Asura October 26, 2004

dufus maximus 

a person who constantly does stupid, idiotic, rediculous shit!
you did that shit again... you're a fucking dufus maximus!!!
dufus maximus by Ms Lena August 30, 2006
That boy ain't right. Buy him books but he's still a dufus.
dufus by Anonymous November 8, 2002