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S.H.P.O.S. 

Designation as a Sub-Human Piece Of Shit, applied by medical personnel in hospitals to their less-than-desirable patients.
In an article published in Values, Ethics, and Health Care, 5 (1980), pp. 226-228, Harold Schwartz attests that S.H.P.O.S. is "an acronym for 'subhuman piece of shit' applied by medical interns and residents to their most unpleasant and uncooperative patients."
S.H.P.O.S. by Michael Zeleny January 27, 2008
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p.o.s.h. 

A popular definition seems to be that P.O.S.H was printed on tickets for P&O cruise ships in the early 20th century leaving India. These tickets were for the more desirable rooms which put you on the Port side going out and the Starboard side returning home as it kept you out of the sun and kept the room cool.

However, no tickets have ever been found which had P.O.S.H on the ticket.

Sources:
www.wikipedia.org
www.askoxford.com www.phrases.org.uk

I suggest that the mistake has been made from the full name of the Cruise Liner: Peninsular and Oriental Steam Navigation Company. Maybe a printing error produced P.O.S.H rather than P.O.S.N.C

A more factual defintion still derives from a shipping term which does not seem to be suggested on the previous source sites.

When boats leave a harbour the shipping lanes work to the rule that you must stay to the left hand side like on U.K roads. When leaving a harbour you therefore keep the Port lights of the shipping lane on the left and the Starboard on the right. However, when returning you keep the starboard lights on the left and the Port lights on the right. Hence Port Out Starboard Home... P.O.S.H
Salcombe Harbour uses this Port Out Starboard Home or p.o.s.h. principle.
p.o.s.h. by Raberto September 8, 2008

P.O.S.H. 

Kyle: Hey, Melvyn, isn't that Kayleigh?
Melvyn: Oh, P.O.S.H.? Yeah, that bitch is such a cockblock...
P.O.S.H. by ProstiTot October 29, 2008

D.Y.G.I.I.L.Y.I.A.H.S.P.J.T.O.S 

From She-ra and the Princesses of Power
Season 5 Ep. 13, The Heart Part 2

"Don't you get it? I love you. I always have. So, please, just this once... stay." - Catra Applesauce Meowmeow
"Do you know what 'D.Y.G.I.I.L.Y.I.A.H.S.P.J.T.O.S.' means?"

Y.D.A.N.-Y.F.W.T.W.P.A.Y.L.W.C.D.U.A.W.I.K.A.A.G.I.W.G.E.U.D.G.T.F.M.P.A.W.A.L.I.A.A.P.O.S.A.Y.T.Y.S.S.B.I.R.Y.A.S.A.H.M.F 

Y.D.A.N.-Y.F.W.T.W.P.A.Y.L.W.C.D.U.A.W.I.K.A.A.G.I.W.G.E.U.D.G.T.F.M.P.A.W.A.L.I.A.A.P.O.S.A.Y.T.Y.S.S.B.I.R.Y.A.S.A.H.M.F
Y.D.A.N.-Y.F.W.T.W.P.A.Y.L.W.C.D.U.A.W.I.K.A.A.G.I.W.G.E.U.D.G.T.F.M.P.A.W.A.L.I.A.A.P.O.S.A.Y.T.Y.S.S.B.I.R.Y.A.S.A.H.M.F
Hookers and/or Ho's on parade
Used to describe a group of slutty girls trying to get attention from the opposite sex using scandalous and obviously whoreish antics.
These HOPS can be eaisly picked out of a crowd for having the following traits:
- exposing wardrobe
- Noses up in the air
- dancing like they are having sex with nothing
- clinging onto people of importance. (Ie - Dj's, club staff, local celebrities)
- excessive amounts of disgusting makeup cakes on their faces
- excessive amount of cheap knockoff purfume
- fake tits

These HOPS usually gather in groups of 3 or more, although you can find them individually, usually under a random man.
"Oh my god Karen, the H.O.P.S. are out again!"
H.O.P.S. by alwaysthat November 5, 2006
While Michele attempted to write her final paper, Cassandra kept asking her to play cards.

Cassandra: "Lets play cards!"
Michele: "You're being a H.O.P.S. right now."
H.O.P.S by ayyyyeeeeoooo July 18, 2010