Eric: "I am sick and tired of cleaning up your crap, Paul. Keep it on your side of the room!"
Paul: "Woah, sorry dude. No need to manstruate at me- I'll clean it up!"
James: "Dude, what's up with Jeff? He's been really crabby lately."
Harry: "Yea, I know. He's probably manstruating."
When a man who is normally quite kind and level headed, goes completely moody and rude for a couple of days. They will have all the moodiness and irritability of a girl on her period, hence MANstrual cycle.
Person 1: Jeez, what's going on with Jim? He's never this moody.