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To destroy, damage, wreck, ruin, or generally f*** something up to the point that it's unusable, or to f*** someone up or pop a cap in their ass. Can also be used to refer to doping a racehorse or an athlete.

"What's the betting someone tries to knobble Golden Thunder before tomorrow's big race?" (Racehorse/Doping)

"I don't give a rat's ass whether he apologized. I want you to go and knobble Sammy the Squealer. Give him a long wet nap." (Mafia/Gangster/destroying someone)
"What's the betting someone tries to knobble Golden Thunder before tomorrow's big race?" (Racehorse/Doping)

"I don't give a rat's ass whether he apologized. I want you to go and knobble Sammy the Squealer. Give him a long wet nap." (Mafia/Gangster/destroying someone)
Knobble by Sid the sneaker May 28, 2013
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Small knob aka micropenis or prepubescent dick.
"That guy who tried to chat me up had a knobble, it was tiny!"
Knobble by Ignitedwhisper June 5, 2020
guy1: hey guys i got a kobble on my knobble
guy2: oh shit, thats in no way good for the girlfriend situation.
chick1: can i come robble your knobble?
knobble by Nick Glenn June 10, 2003
Slang word for 'Knob'.
"Davey is such a dick"
"I know, he is such a knobble!"
Knobble by Vic and Kate Stanley August 29, 2005
person one: how was henry last night?
person two: everything was great but he has a knobble
knobble by CharlotteBrontë November 30, 2018

A Knobble 

When you land a 98% but it doesn't matter because you wanted a 100. Based off the Geometry Dash Fail on Bloodlust when the Player Knobbleboy died at 98%
Ling: Darn it! I got a 98 on my test my parents are going to kill me!
Mason: Thats a Knobble
A Knobble by NotA10YearOld June 5, 2018

double bobble knobble 

whence both parties participate in a mutual 69 bob knobb
“Did you take that double bobble knobble last night jessica?”
“Yes his double bobble knobble game was so aggressively penis.”