irritate my soul 

When someone is just irritating you and your should entirely and you want to blow the whole world up.

Dude, you irritate my soul.

irritate my soul by glittersparkles April 18, 2018

irritant 

Someone who in their free time texts other people useless information that is not wanted or needed.

Someone who day drinks and uses other mood enhancing chemicals and then proceeds to text people who were otherwise having a great day with their family. That person is a total irritant, a disease if you will.

irritant by Momo1010 November 16, 2013

Irritable Thong Syndrome (ITS) 

The annoying discomfort resulting from your thong rubbing your booty the wrong way.

Lisa: “You don’t look happy, what’s wrong?.”

Cynthia: “I bought this lace-trimmed thong because it was really cute, but it’s giving me a terrible case of Irritable Thong Syndrome (ITS).”

Irritable Thong Syndrome (ITS) by kraftgirl September 30, 2009

irritatei 

Irritation of the skin

I dont got schurft i just got "Irritatei" on the skin.

irritatei by Beertje February 9, 2009

irritarded 

When an individual is extremely irritated to the point where their speech becomes impaired.

Jim was so irritated with Jess he became Irritarded.

irritarded by Saffmat November 20, 2014

irritatedly 

An botched attempt to demonstrate your grammatical mastery

and we watched Pete irritatedly trying to get the bear trap off his dick

irritatedly by Esa4 September 14, 2019

Irritable body shock 

it’s when you are doing excerises and then you go into shock for a few seconds and you zone out. Feels like time stopping

Omg I was working out and then my body went into irritable body shock

Irritable body shock by Birchtreeeater November 16, 2021