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to tell someone to stop talking. meaning "be quiet" and "stop talking", usually considered to be rude.
dan: that's not what you said.
greg: "shut up dan!"
teacher: we don't use shut up in my classroom.
dan: somebody just did
shut up by themostawesomest December 9, 2008
to tell somebody that they do not know what they are talking about or are just plain irritating
Jord: "I like The Beatles"
James: "I know!!! Shut up Jord!!!"
Tom: " Yeah Jord, shut up!!!" *Tom slaps Jord round the back of the head*
shut up by James Stone December 6, 2006
shut up by mr fazbear October 17, 2017
Shut your mouth beau
You're supposed to be a PhD holder
Not a screw up stalking people and sitting on urban dictionary writing stupid definitions

What is your problem
You need a good fucking backhand slap to your face with my left foot
Don't waste your life Doc
Put your life to better use than being a cunt

S
Shut up and eat some fucking humblepie
Shut up by PurpleStarr January 29, 2019
Usually considered 'rude' used to tell someone to be quite. Sometimes, shut up is used to express amazement, even if the person it is being directed to is not talking.
"Shut up Meg."

-Peter Griffin

or
"Shut up!"
"I didn't say anything..."
shut up by modern wards June 24, 2016