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A combination of the words "fake" and "shit". Someone who is shake is "fake as shit".
"Lauren is so shake. She didn't even invite us to Moe's.
Shake by JRMac October 3, 2013
alternately, in the 70s and 80s California Bay Area, dried marijuana leaves were known as shake.
Jimmy:"hey man, I got a bag of weed"
Joran: "groovy man, is it bud or SHAKE?"
shake by shiatbiatch September 10, 2010
To throw up in a sink.
Man, after shotgunning that last beer I shaked in John's sink.
Shake by Anclark November 4, 2008
A true asshole. When you react with retaliation ten times worse than the action inflicted upon you, you have successfully pulled off a Shake.
Guy #1- Yo dude, what happened with you two?
Guy #2- He called me an asshole so I grabbed a hammer and fucked his nuts up with it.

Guy #1- Dude you just pulled off a Shake bro.

Guy #2- Don't compare me to that ass hat
Shake by Mr. Highway September 16, 2013
"Shake" is a word that combines the words "Bake" and "Shower" referring to smoking cannabis in the shower, usually in the morning.
"Yoo so I got up and shaked, then Uniqua called."
Shake by Sturbz August 6, 2012
When a woman has a nice body and when she walks, the good parts jiggle, but just a little.
Did you see the shake on that girl who just walked by?
shake by chrome7 January 25, 2013