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Humor Leper 

A killjoy that sucks all the fun out of life with their pretentious, politically correct bullshit and find every joke offensive. Usually a miserable dolt with zero creativity and sense of humor, they infect their hosts and surrounding and destroy any chance of a good time.
Wow! I didn’t know that Dave was such a Humor Leper, you can’t crack joke without getting a lecture from him, leave him home next time
Humor Leper by Lord evil May 23, 2013
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social leper 

Someone who is so anti-social that if you hang around them a lot, you will find yourself becoming like them. Sort of like you caught their leprosy.
I used to be the biggest thing ever at this school. Then, I started hanging out with this social leper and now I have to beg for people to hang out with me
social leper by Alex Pearson April 29, 2006

social leper 

someone who can ruin your status with others just by hanging out with you
Did you hear about poor Steve?
Who's Steve?
My point exactly. He is the football quaterback. Poor Steve met a social leper and now no one hangs with him anymore
social leper by Charece May 5, 2006

PFLEPER (pronounced F-leper) 

Pfizer employee who just got canned. In addition to losing all dignity, it is learned that scores of many other people knew about it months before the terminated person. These people avoid the person losing the job as if the terminated person had plague or leprosy; hence, the invocation of "leper."The employee losing their job also loses their office, support, email, benefits, etc. And to a large degree spirit and health.

Though originating at Pfizer, the largest pharmaceutical manufacturer in the world, the term "PFLEPER" (pronounced F-LEPER) may be used for any terminated employee anywhere.

Pfizer puts a "P" before many words beginning with "F:" eg., Pfun, Pfinance, Pfamily, etc. And prefixes a "PF" on just about any other word it uses. Cute that way.
Have you heard about David? They're letting him know on Friday he's out. I think he may know. He even looks like a PFLEPER (pronounced F-LEPER).
Even the Zoloft} and Viagra don't seem to be helping.

He's really Pfucked.

Neon Green leper Weave 

If you are in a situation where you need to leave, use this then exit.
Also can be a person with a neon Green leapord Weave in.
And if a person is random and you want to insult them, use this.
Uhhhh.... neon Green leper Weave *exits*

Look she has a neon Green leper Weave

Girl, u a neon Green leper Weave!

gay leper 

a person who has no faith in a normal or "straight" life once they have encountered the wonderful world of cock. After all of their time is dedicated to the penis, they are far to weak to carry on with any other aspect of life.
"I'm sorry guys, i can't go with you. im far to weak because I've been up all night worshiping other men's peters. I have the gay sickness!"
-Rocky Marcum
gay leper by GilBREATH January 17, 2004
Whilst having sex with a girl keep a sausage (raw or cooked) in your hand. After a few minutes remove your penis from her as you shove the sausage inside. Tuck your penis between your legs and scream. As she turns around she will still feel something inside her but it will look like your penis is missing.
This is called The Leper.

Bonus points for adding ketchup or fake blood for extra realism.
'I'm going to have sex tonight!'
'Make sure you do The Leper, here, take this sausage.'
'You're a great friend.'
The Leper by The 413 August 25, 2012