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Smith and Wesson 

When a woman is on all four, head down ass up etc., and another party inserts pointer and middle finger in to the vagina and thumb in to anus. In order to successfully complete this move you will be making a pistol type shape with hand.
B: Did you bang that girl last night?

M: Yeah I gave her the Smith and Wesson
Smith and Wesson by RealChez May 29, 2017
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Misters Smith and Wesson

Used when talking about a concealed S&W revolver on your person. Generally to avoid the panic caused by declaring you are carrying a revolver.
Jeff: I wish we had a gun right now.
Sally: Don't worry, I brought Misters Smith and Wesson with me.

dirty smith and wesson 

The act of shitting in a tub sock and hitting someone with it.
That fucker Fred hit me in the face with a dirty Smith and Wesson

Glaxo Smith and Wesson 

When you campaign for three terms of service from age 5 and then then dehistorify you and tell your whole family to eat dick and starve
I've been hit by Glaxo Smith and Wesson
Glaxo Smith and Wesson by Cody5050 January 27, 2022