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I don't mess with 

A polite way of saying that you don't have, and don't want to have, anything to do with someone or something.
I don't mess with Matt Lauer or the Today Show ... and that's a very nice way for me to put it!

I want to say one thing to the American people. I want you to listen to me. I'm going to say this again: I don't mess with that woman.
I don't mess with by Philosophistry November 17, 2010
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don't mess with texas 

Something that a typical Texan will say...anyone "messing" with Texas is an impossibality because states are not allowed to have conflicts with other states let alone foreign countries...you dumbshits
"Don't mess with Texas!"
"go back to Grade school!"
don't mess with texas by asdfsa October 7, 2006

don't mess with my man 

When a crazy bitch think you trying to steal her man, and tell you to leave him alone before she cut you.
Emma: Is that Josh.
Josh:* waves at Emma*
Alex: Are you flirting with my man? Don't mess with my man bitch.

Nov 15 Don’t mess with ur short friends day 

So basically the people who made the days to annoy short people this day will have u annoy them and it’s on the 15 of nov
Nov 15 Don’t mess with ur short friends day U annoyed me and shorter so I get to slap u and hit u and annoy u

i know karate, i know kung fu, you mess with me, i mess with you!

I think I'm cool and I totally pwn you so don't mess with me!
One might say "i know karate, i know kung fu, you mess with me, i mess with you!" To ward off unwanted attention from bullies. Mostly unsessful.
Also, a phrase used often by geeks trying to sound cool.

Don't mess with texas 

George Bush is teh 1337 and he came from TEXAS so, don't fuck with him, or j00'll be nuked biotches!
Don't mess with texas you stupid sand nigger!

dont mess with texas

George bush is de-1337 of ur face and will kill kerrys donkey face, iraqis must die, and they r so yay for bush. now kerry will drink his urine cuz now he has to kiss bushs' ass
dont mess with texas by HellSing March 28, 2005