A polite way of saying that you don't have, and don't want to have, anything to do with someone or something.
I don't mess with Matt Lauer or the Today Show ... and that's a very nice way for me to put it!

I want to say one thing to the American people. I want you to listen to me. I'm going to say this again: I don't mess with that woman.
by Philosophistry November 15, 2010
Get the I don't mess with mug.