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chromie homie 

The name you give to your mentally challenged friend (for they have an extra chromosome)
"Yeah I know David has autism but we're chill, he's my chromie homie"

"That special ed kid is my homie with an extra chromie"
chromie homie by TheRollexWatch November 28, 2016

Coromies 

People you spend the government mandated coronavirus lockdown with.
I was chillin with my coromies during the Seattle coronavirus lockdown.
Coromies by EnemyBread March 23, 2020

extra chromie 

When you or someone else has an extra chromosome causing them to be retarded
Bro I think Melisa from the Voice has an extra chromie

chromessi 

A “Chromessi” is a sexual act where a woman jerks a mans penis off with her feet. It occurs when she does it in a way that is so impressive she can be compared to renowned soccer star Lionel Messi and his spectacular footwork.
She gave me an amazing Chromessi
chromessi by Exvis December 27, 2020

Homie with an extra chromie 

Person with Down Syndrome, due to the fact the condition is caused by a person being born with 47 chromosomes instead of 46.
That guy with Down Syndrome is my Homie with an extra chromie.
A chrome valve cap for a tire, desired by teenagers to stylize their bicycles.
That BMX would look real nice with a pair of chromies.
chromie by Sammy Fan April 27, 2004