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It's a combination of letters on your keyboard that you use on your friend to piss them off.
Guy1(on laptop)

Guy2:"clicks alt f4 and deletes the page Guy1 was on"
Guy1:WHAT THE FUCK MAN!?!?!!?
Guy2: ha ha get prank bro you must get of that loli henti.
ALT F4 by Daggermaster9900 December 6, 2018
Alt F4 is the prank those 9 year-old's follow.

9 year-old playing Fortnite: Hey, do you know a hack to get a Victory Royale and everyone instantly dies
Pro: Yes I do, hold Alt and F4 at the same time and then let go.
9 year-old: (Gets off game, raging, and destroying his keyboard)
Alt F4 by ADEEPOCEAN May 21, 2020
A key combination / panic spell that you must use quickly when you're about to lose or die in a video game (on PC) to escape your inevitable demise. Some MMOs however implement penalties for using this to escape doom however as it is considered cheating.
A: "Yo I was playing Roblox Jailbreak and this cop was about to arrest me so I've alt f4 out."

B: "What, I tried that on League of Legends and I was suspended from playing any servers."

A: "Oh Shi-"
alt f4 by Kit Rat January 27, 2019
It makes you win.
Lol dude. I was in the middle of this game on the computer and I was so close to winning 1million dollars.!
Than I pressed Alt F4 and i totally won...
Alt F4 by I are teh hax March 6, 2009
Makes you fly in most video games
James: Yo, how do you fly in this game
Reed: Alt F4
James: Sick!!
Alt F4 by XCtryhard April 27, 2021
Guy 1: If you ALT F4 then get an invisibility glitch
Guy 2: *Leaves game*
ALT F4 by I have Diarrhea November 8, 2019