YOPO 

You only Pass Once.

I haven't studied for that Acio Test Yet. YOPO.

YOPO by naggyt October 24, 2012

YOPO 

Is the acronym for "You Only Poop Once." Often used with a hashtag.

Gage: "Yo dude, I took a massive dump before french class."

Jas: "Well you know what they say, YOPO"

YOPO by SxJas March 7, 2014

Yopo 

Eigentlich Anadenanthera peregrina genannt. Illegale Mixtur aus Yopo - Samen die hauptsächlich bei Indianischen Völkern benutz wird um in einen Trancezustand zu gelangen. Der Hauptwirkstoff ist DMT. Es wird einem durch ein Blasrohr in die Nase geblasen.

Yopo wird selten auch als harte Droge verkauft. Sie führt aber miestens zu erbrechen und wird von den meisten als sehr unangenehm beschrieben

Yopo by LaChris March 29, 2014

YOPO 

You Only Poop Once

Friend: Man, don't buy that expensive house just for it's bathroom!
Me: Fuck that, YOPO.

YOPO by Butt Chin December 18, 2012

Yopo 

the legal marijuana that you can buy at the corner store that suppose to be used as incense

hey man, wanna go smoke that yopo? it doesn't show up on a drug test

Yopo by Yopo King June 30, 2011

yopo 

yopo is another word for {yo} it is so much cooler and better and its the new thing to hit the teen language.. also it was created by a typo of the two most amzing people in the world.. spred it on ..

ex: Yopo, wats going on.. wanna hangout later

yopo by themostamazingpplintheworld March 25, 2005

YOPO 

Yopos can be characterized as a dangerous specie that will bring mayhem to your life. Whether it’s indestructible or irreversible, the damage he is found doing is simply unacceptable. If you find this creature snarling in your ear, seek help before it’s too late. Hobbies include collecting suits, making British kids laugh, and offering hazardous stock advice.

*human breathes air*
Yopo: “please don’t do that here, thank you”

Hey David, how’s your day?

David: Was going great before I lost my whole savings because of Yopo.

Yopo went to town and caused perpetual damage.

YOPO by MMJ Mashgiach November 23, 2021