1. The suffering and general lack of energy/ambition that sometimes results from living the lifestyle of a gay man. Can be induced by homophobia, excessive grooming, closet living, etc.
2. When straight people get tired of dealing with gays and the gay lifestyle. A straight man with a gay roommate may often feel gay fatigue.
1. "Hello, I can't come to work today, I am suffering from gay fatigue."
2. Scott become weary with gay fatigue after overhearing yet another conversation about ass-fucking
MTV has caused more gay fatigue than any gay guy or lesbian could dream of. Imagine, 20 million teenagers a day learning to think being gay is so normal that it deserves coverage 24/7.
Yo man, did you watch CNN this morning? No, I'm already suffering from gay fatigue and I avoid turning on the TV or reading the news the entire month of June.
Rosie O'Donnell was considered the "Queen of Nice", but once she came out and proclaimed her gayness, she conformed herself to the typical gay attitude and lifestyle. She has pushed her opinion on whoever will listen to the point of getting married to spite the government. Now society has “gay fatigue” because of Rosie O’Donnell’s constant outspokenness. It was news when she first “came out of the closet”, but now its just plan annoying.