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grandspawn 

grandchild, especially one of questionable origins. Comes from the tv series Angel, when the Fang Gang learns that Cordelia has been impregnated by Angel's demon-spawned son Connor.
Gunn to Angel: "Congratulations, you're going to have a grandspawn." (Season 4, episode 16)
grandspawn by braxxx October 17, 2008

Grandpaspaghetti

A tiktok creator who comments under nearly every post with “grandpa lol”.
*opens up a tiktok videos comment section

Grandpaspaghetti: grandpa lol.

Person: You’re everywhere bro!

grandsister 

When your sister marries your grandfather.
Dude your grandsister is totally hot.
grandsister by Big Man25 January 8, 2011

Grandsister/Grandbrother 

When your son/daughter has a baby with your mom/dad, said baby becomes the your grand-sister/grand-brother.
Today I'm taking my Grandsister/Grandbrother to the park.

Grandsister 

DUDE YOUR GRANDSISTER CAN COOK? AWESOME!
Grandsister by Twight0931 July 30, 2017

grandsister 

Grandsister is your grandmothers sister, yeee boiiiii
Boy 1: Ohh that old hottie
Boy 2: That's my grandsister.