1) The best show you never saw. The Emmy Award winning show which survived for about two and a third seasons before being cancelled by Fox. Failed due to being far too smart for a mass audience who would rather watch Pamela Anderson "act" on Stacked.
2) Any act of getting completely screwed despite undeniable skills.
2) When Michael Bluth was repeatedly passed over in favor of his amusing, inept, "illusionist" brother, Gob for leadership of the Bluth Compay, he was given the AD treatment.
From Arrested Development:
"Lucille: Well, apparently, mood-altering medication leads to street drugs. That's what this very handsome young doctor said on the Today Show.
Michael: That was Tom Cruise, the actor.
Lucille: They said he was some kind of scientist..."
(if you don't get the above quote, don't bother watching the show)