Saying used to described uncomfortably cold situations when you feel as is if your face, hands and or balls may possibly off due to severely low temperatures.
A general feeling of one being cold.
Frisco: "Hey dude can I borrow a sweater for my walk home."
Jonny: "No man, I'll never get it back, quit being a pussy, it's only 45 degrees out there."
Frisco: "C'mon man, it's cold in the D"