UPI 

Un-Identified Party Injury, Mysterious injuries discovered after a a period of intoxication.

This morning, I woke up with a UPI on my leg.

UPI by McBain February 7, 2002

upi 

a word used in instant messaging when you accidently have your right hand fingers off by one on the home row on a qwerty keyboard.

you're

becomes

upi
re

upi by sirtalksalot June 5, 2009

Upi 

An indian girl who moved to the u.s.
She thinks she is ugly but in reality she is very pretty.
She likes wanna-be gangstaas and black people and likes it when people mistake her for mexican c;

Black Man- Yo dawg, who is that mexican girl?
White Man- You mean Upi? She's not mexican...shes indian
Black Man- Ahh...well she's hot

Upi by noahc; November 30, 2010

UPI 

Unidentified party injury

dude...where'd you get that huge bruise. I don't recall. It's a upi from Saturday night.

UPI by rawr kitty December 30, 2016

UPI 

Universal Place Identifier

The UPI for Queretaro is queretaro

UPI by blabloz September 19, 2019

UPI 

Universal Prostate Institute.

A made-up institution to serve as an excuse when somebody asks where you graduated.

George: Do you have a degree in computer science?

Johnson: Oh yeah, I graduated at UPI...

UPI by Bin_NoGoutHavinAss_Chang January 12, 2022

Upi Dupi 

Upside down double penetration.

A girl lays on her shoulders and 2 guys penetrate her pussy and asshole.

Jackie raised her holes to the sky and rested her weight in her shoulders as tony and mike stuck their dicks in her pussy and asshole.

upi dupi isnt gay but it can get weird

Upi Dupi by Tony Oats November 12, 2010