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Twizzle on it usually accompanied by a raised middle finger means 'go f&ck yourself'.

Used by secondary school kids in the late 1990's it has a level of popularity in West of England still.
''Bloody cheek! She wanted to knock me down on that quote:, I told her Go twizzle on it, cheeky mare''
''Can I borrow £20? ..answer ''Go twizzle on it! finger gesture you never paid be back from the last time!''
by Oakbark July 06, 2018
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