"Hey John, I was talking to your sister, and from your family tree, it looks like you guys had a pretty bad case of twinception, like 6 generations in-bred"
"That's no big deal, my twins might be in high school and having sex on a regular basis, and one of them have double-down syndrome, but it isn't any different than my household growing up... Like father and mother, like son and daughter i guess."
When a person on twitter, usually female, is not as attractive in person as they seem to be in their avi/twitter pictures. Usually due to filters/excessive makeup.
"Dude, remember that chick whose DM's I dove into last week after she posted that cleavage-heavy selfie?"