Interstate 405 runs north south through Southern California. Instead of saying "the 405 Freeway, Californians just call it "the 405".
Take the 405 to the 101...
by Boho chick March 24, 2014
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Heavily congested freeway that runs generally through the west-central part of Los Angeles, California.

(There are also interstate highways with this number in Washington & Oregon, but the California version is the most famous.)
The gridlock on the 405 is legendary throughout the country.
by Zalis December 8, 2003
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1. Interstate 405, which runs through southern California and Los Angeles.

2. called “the 405”, central Oklahoma and especially Oklahoma City. So called for its area code.

3. 405 "Method Not Allowed", an HTTP error code.
1. The 405 has archetypal bad traffic.

2. Back in the 405, we used to have it so good.

3. Um, John, why is there a big 405 on the screen?
by tangles10 September 12, 2010
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I be reppin' da 405 son.
by Kaiyo November 4, 2003
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from the http error message 405 "forbidden"

Often means "over the line"
Stop man, that room is 405

You take that back fo' that was 405
by Da Zeg January 8, 2005
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the most poetic 3 digit number ever. It's perfect imagery and makes you think of those moonlit nights when you just feel so tired that you feel so great and the lights are just perfect.
by bengibbard March 22, 2009
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a cool bus that drives around town and picks up ppl
here comes the 405

here comes the bus 405

man that 405 is cool
by 405 September 14, 2004
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