Referring to the first, yes it is derived from STFU which means "shut the fuck up" Stuff you is a tamer version more widely accepted, yet still holds the same message of shutting up.
dude: hey why dont you see me some time?

chick: stuff you and go away!
by TEEG February 20, 2006
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Verb.

Derived from the term stfu.
KeWtLiLaNgELgUrL69: hey u sem kewl kan i add u to mah budilist??!/1
Regular Person: Stuff you.
KeWtLiLaNgELgUrL69: wat/!?1/
Regular Person: ::blocks::
by Jerk The Mom December 02, 2003
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Stuff You Should Know is a podcast that is on iTunes, presented by HowStuffWorks.com.

Howstuffworks.com is a journalism website on which there is an article on many a thing.

SYSK, as it is known, is hosted by Chuck "Chuckers" Bryant, and Josh Clark.

Stuff You Should Know is, in my opinion, good. Although this, many people accuse it of being poorly researched and just plain wrong. So be it, it's your right to dislike it.

So, I suppose if you're interested, take a look.

Also, there are many Howstuffworks.com podcasts,such as

Stuff You Missed In History Class;
Stuff Mom Never Told You;
Stuff They Don't Want You To Know;
Techstuff,
and Stuff From The Science Lab.

among others, I'm sure I missed at least one
Stuff You Should Know is an audio podcast from Howstuffworks.com
by SYSK army June 29, 2010
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To put cram ones testicles fully inside a woman's vagina. (See also: "T. neck that cavity")
"Spread out Autumnal-themed tablecloth and get your ass on the dining table; I'm gonna stuff you with my giblets and t. neck that cavity!"
by tim_finnegan November 13, 2019
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When you suffer the rath of Gru, he will stuff you in a pizza then cook you and eat you. Basically when someone gets really mad at you, they will stuff you all in the crust.
Person 1: “You’re bad at making memes.”
Person 2: “I will stuff you all in the crust.”

Person 3: “oh haha I get the Despicable me reference.”
Person 2: “stfu retarded normie.”
by Therealdankmemer017 November 06, 2018
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