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Southern Tenant Farmers' Union (STFU): Large labor union, formed in Arkansas in 1934, which lobbied the federal government for better New Deal reforms. Dissolved in 1960. Commonly causes mirth among US History students who are aware of the acronym's double meaning.
Teacher: Joey will you please tell the class about the STFU?

Class: Hahahahahahahahaha
by jer February 24, 2005
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17
Shut-the-fuck-up: a term used when a normal request for someone to be quiet seems to fall on deaf ears; may be used in either a normal or assertive tone of voice.
Honey, would you be terribly offended if I asked you to please STFU for five minutes?
by Monkster1 June 24, 2010
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18
Shut the fuck up. It's simple. When you are annoyed with someone who won't stop ranting on instant messaging, you type "stfu!!" But be sure to limit yourslef to two exclamation points, though, because three will look too angry. You could also type two exclamation points and then a "1". Like this: stfu!!1. This way, the third exclamation point is there, but only in spirit. This puts a little extra anger, but not so enough to make the other person angry at you. :)
~On instant messaging~

like_totally_cheergrl07: like omg omg omg we like totally had so much crap to do today in like science because the teacher is like so bitchy and she doesn't get that I have a life! I mean COME. ON. Wtf???!!!
xXxmy_heart_bleeds_blackxXx: stfu!!1
by Cexy October 13, 2007
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19
1.Acronym for SHUT THE F*** UP
2.For same thing for u
1.Joe:Hahaha you suck!
Jack:STFU
Joe:No u

2.Remma:Your lookin' hot
Jake:stfu too
by spike09 November 14, 2009
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20
Shut the fuck up.

Or, if you're in AP U.S. history, the Southern Tenant Farmers Union.
The AAA told the STFU to STFU
by bishthemighty February 20, 2011
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