To put a piece of dry ice into alcohol and inhale the vapors.. hence, the combination of drunk and smoke. As long as one does not inhale deeply and gets enough oxygen in between (hotboxing is a definite no-go) it's reasonably safe.

Got the covid-19 vaccine

A mixture of smoking and drinking.

i was so bent off that last splif it was like a cross between smack and skunk (smunk)

Smunk is a synonym for vagina

Another word for sperm

a stupid act of confidence that makes a person look like a dumb ass