When one is high from marijuana and drunk from alcohol at the same time.
I've been screwballing all night.
by SouthJersey March 21, 2009
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1: A fool; and idiot; someone who is crazy

2: A type of baseball pitch
1: Man, he's a nice guy but he's such a screwball sometimes.

2: Woah, did you see that screwball?!
by zeemeister April 23, 2011
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A 50/50 mix of Powder Heroin and Powder Cocaine. Creates the feeling of being in a relaxing warm bathtub mixed with the desire to complete an insurmountable task. This volatile mix is usually mixed into a drink because snorting it is too risky.
Guy 1: "I heard that guy over there is selling "screwball"."
Guy 2: "That stuff will mess you up for days."
by Big Poppi July 29, 2014
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A pretentious fuck who just wants to bang every girl that hey can. Wears vinyard vines and designer collard shirts and shorts paid for by daddies money, oh yeah he probably drives a BMW or Volkswagen Golf.
Bryce tried to fuck Jessica and Tiffany at the party, what a screwball
by Wordplayer44 May 8, 2016
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Screwballs means 'crazy people'.
'I just met two real screwballs'. Oddballs. Fruitcakes. Loaf heads.
by Dannyloco1 December 25, 2011
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