to "gangbang" a girl with several friends.
Think of an actual train - one goes over the tracks, and then another. Now, say these trains were friends of some asshole, and the tracks were... you get the idea.
by babette January 1, 2004
When a bunch of guys have sex with the same girl one after another with no break for the girl
Yo tonight were going run train on that bitch Jenny
-Cool hopefully i'm not the caboose.
by bloddyazzcheese February 15, 2009
To call your friends to preform various unforgivable acts of a sexual nature on one female in rapid succession.
I'm 'bout to call bovice. We 'bout to run train on you, bitch!
by un4gvable1 March 11, 2008
to have sexual intercourse with a girl, with the help of one's friends.
"Bitch if you don't leave RIGHT NOW me and Bo Vice gonna run train on you!"
by mechaduck November 5, 2007
To do work on multiple people in a game or anything that has competition. IT IS NOT ANYTHING SEXUAL.
Jared: Wanna run train in gears later?
Dave: Yessir!
Jared: Don't invite Sam or else we won't be able to.
by Grogdog June 1, 2011
to drive a train, as a train driver wood

not what all of u r thinking, PERVSSS
tim: do you wanna go run train
timothy: u mean like drive a train
tim: yeah what else would i be talking bout
by timmydee32 June 11, 2007
To beat the shit out of somebody or "go crazy on their ass".
"I'm about to run train on that cunt!"
by pistol08 October 8, 2008