Intoxicated; extremely drunk

pie-eyed means to be intoxicated, derives it's name from the dialated pupils that people get on certain substances, pupils as wide as pies, in the hippy "jam band" scene being pie-eyed usually refers to being intoxicated on lsd, mushrooms, ecstacy, molly, or char

To be stoned or high. As coined by my buddy Werm.

when you've smoked so much weed, that your eyes are all squinty and look like mini slices of pies!

A drunken hysterical sensation due to eating too many pies.

to be pissed, originated from pi**ed, which could almost be pronounced (pie eyed)