Verb; To smoke marijuana. To smoke weed. Term mostly used in Queens, NY. Originated by the Smart Crew. Sometimes, other constantans substitute the first letter of the word such as "buff, muff, fluff, huff, wuff, etc..."

Noun; Marijuana, weed, etc...
Where's Warren? He's duffing in the basement.

Anyone got some duff I can buy off them or throw down on?

GR only duffs that pure premium.
by serious faces May 19, 2009
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When you are fucking a girl for the first time anally, you pull out too fast and the girl begins to shit uncontrollably.
Person 1: Dude OMG I heard you got with (girl's name) last night ..
Person 2: Yeah I'd rather not talk about it, it was a bad case of The Duff.
by The Duff Veteran November 9, 2010
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Dumb(or Designated)
Ugly
Fat
Friend
But really, those describing words do it an injustice. Every group of friends has a duff. the one who's approachable, a little less popular or pretty, and doesn't quite fit in. But the friends in that group also have more friends, and could be their duff. So in reality, we are all duffs.
A boy in my grade called me a duff before I knew what it meant. I found out two seconds later from a girl next to me, that it meant Dumb, Ugly, Fat friend. But she also said that I'm none of those things, and what he had said was highly redundant. (She started laughing and said really loud,"But he probably doesn't know what duff means either, and that a few of those words perfectly described him!")

Duff is also described in the movie, "The D.U.F.F". I recently watched it -for MATURE audiences only- and it gives plenty examples.
by innocence_is_treasured;) July 29, 2015
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1. Bollocks. Rubbish. Not worth a fuck.

2. The bass player of Guns n' Roses, 10 Minute Warning, Velvet Revolver
1. I cant play that duff guitar you bought, its the cheapest lump of shit I've ever seen!

I was late for work again because my duff old Ford Fiesta broke down again!

2. Uh, well... Duff McKagan plays bass.
by Saviour of the real January 20, 2007
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Its a person that is usually more big than normal ppl. she is usually brought to a party or something and they are used to make a person to look better. So maybe you are one maybe not. Ppl may joke around and say you are the duff duff. Sometimes ppl will be serous when they say that also. Another thing is tht they may not tell u that ur a duff duff.
lol Mia is totally the duff duff, no what abby is!!!! :p
by Krazy💖 September 7, 2017
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A person who by society's description doesn't fit in with their friend group, being more approachable, and the one to go to ask for their friends numbers.
Guy: Heyyyyy

Duff:(THINKING: OMG HE's TALKING TO ME> HE'S SO HOT) Yes? What

Guy: Well, i was thinking... would you like to...

Duff: Yeah...?

Guy: What's the hot girl on the left that you were talking too's number...?
by satan666jks May 25, 2015
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The pot left over after being "smoked" in a vaporizer.
I'm gonna make some butter with this duff.
by Bititall June 18, 2006
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