To get hit really hard or to shut someone up.
Jamal and Cherri were arguein and she cocked back and mouffed em.

or

-when u are observing an arguement and one of the two parties says a snappy or quitck witted comeback it is appropriate to yell "MOUFFED EM!"
by K-roc March 15, 2007
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A physical malformation resulting from the over-consumption of the popular party drug mef, or "mefamphetamine."
If you don't lay off the mef, you're gonna get da mef mouf.
by ericalexander June 28, 2011
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Saying from "The Candy Hole" catroon series by Brian Frisk (The Frown).

Originally quoted in the first episode "Candy is Good" and continued to be quoted through the other episodes.
Episode 1: Candy is Good

Rabbit: I like candeh.
Cat: I know.
Rabbit: I know.
Cat: I like to eat it in my mouf.
Rabbit: Iz gud.
Cat: Iz soo gud.
Rabbit: In da mouf.
Cat: I knooow!
by eatdacandehsharing March 8, 2010
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Jewelery that goes in your mouth; i.e. "a grill/grillz"
Got me a new piece of mouf jury today...dropped an ass load of cheada on it, but I luv dis grill.
by smack mouf November 14, 2011
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When batman looks like he has dik in mouf.
Oh shit waddup he got dik in his mouf.

He likes to get dik in mouf.
Dik in mouf is healthy.
by meiiscancer June 14, 2017
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a chick that took a very big load in her mouth.
"dude i saw a pic of this broad that had cummy mouf. it was all the way down her chin."
by 9deuce June 23, 2008
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a slang term used to refer to the roof of a persons mouth. Normally used in a threatening manor.
"you best not talk bout my mama like that or someones gonna get punched in the mouf roof, and its not gonna be me"
by Garrett Dunning February 10, 2009
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