is a slang for irmão, which means brother in Portuguese.
hey mano let's pick up some chicks
by sacht March 11, 2014
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1. man orgasm (n.)(v.)(adj.)

manos - one man, multiple orgasms
meno - three or more men, orgasming in unison
menos - three or more men, orgasming multiple times
I mano daily with Derrick.
by Rondo Mowad September 25, 2007
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Adjective - Crazy in an uber aggressive, destructive, sometimes junky, and always testosterone injected sort of way.

Originating from the first Mortal Combat game character Kano, who had a metal plate in his head he liked to head-butt opponents with.
That new Ford land destroyer is fucking mano! Damn thing comes standard with a gun rack and a 12 pack.
by tinymonkey June 24, 2004
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A sound effect to describe almost any situation
Person 1: and then I was like....are you listening to me?!
Person 2: mano..... (darty eyes)
by Crendy September 20, 2007
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The term is Spanish and literally means "Hand to Hand" as in unarmed combat. However in its modern incarnation the term is used in any scenario where two (usually male) individuals are going to have some sort of competition. Eg Darts, Snooker, an actual fight, even videogames. It is rarely a serious threat.
"Come Hotshot think you can take me at Multiplayer goldeneye? Huh? Ok just you and me Mano a Mano"
by Jack Karch May 29, 2006
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A Portuguese expression to describe a fight between two people
Vamos andar à porrada, tu e eu, mano-a-mano
by HistoriaViva September 10, 2018
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This expression could come either from italian or spanish, it literally means "hand to hand" and it is used to indicate an argue, a verbal fight between two people.
"I had a mano a mano with John yesterday, i hate when he talks to me like that."
"You and John should stop with those head to head discussions..."
by Tobeeto dudy flappucine March 24, 2017
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