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the intravenous injection of a drug. which means using a needle to get a drug into your vein, to absorb it through your bloodstream. a lot of drugs can be taken this way, the most commonly associated drug being heroin.
Layne accidentally overdosed by mainlining heroin.
by two blue lights November 10, 2008
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May 15 Word of the Day
A few weeks ago, no one had β€œcheugy” in their vocabulary . Now everything is saturated with the word. It’s in our heads. It’s in our homes. Everyone is asking: β€œAm I cheugy? Am I a basic ass bitch? Am I GUILTY of being cheugy?”

The proliferation of cheugy in the mainstream discourse can only be attributed to one source: mental terror. It’s an orchestrated psychological trap to make you question your tastes and interests in the eyes of others.

You are not a cheug. YOU’RE PERFECT!!!!

It is very suspicious that the cheugy mascot is a Minion, a literal cyclops, a deformed
yellow panopticon in overalls ... do not let the all-seeing eye to control you. Be vigilant. Resist cheugy psyops.
Becca is another victim of cheugy psyops. I saw the garbage truck take all her Ugg boots yesterday. She even removed β€œI LOVE The Office!” from all her dating profiles. She’s unrecognizable.
via giphy
by Callmemaybe69 May 12, 2021
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2
The act of binge-watching or binge-listening all episodes of a podcast or all episodes in a season of a TV show without breaking for sleep.
Mackey: Where were you last night?
Buddy: Aw, man, I was mainlining "Sense8." After the second episode, I was addicted!
by GypsyBowl July 05, 2015
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3
the act of taking internet lingo and applying it to real life conversation

matt: I walked by a group of kids taking a test and said, "fucking scrubs."
joel: dude, you were totally mainlining.
by Taxt April 16, 2009
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