This is a drug belonging to the group of Non-Steroidal Anti-inflammatory Drugs (NSAIDs) and are used mainly for pain relief (analgesic). The main mechanism by which these drugs work is by inhibiting cyclo-oxygenase (COX) which prevents the production of prostaglandins.
Mazzy says: "My head hurts"...
Porousi says: "have some ibuprofen babe, it will fix you right up"..
Mazzy says: "OK"
by Soriam October 19, 2007
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Ibuprofen is a nonsteroidal anti-inflammatory drug.
Basically, what that means is it stops inflammation and fevers.
For the more knowing, it inhibits things called cyclooxegenases.
Mainly, cyclooxygenase-2.
Cyclooxygenases make things called prostaglandins; they promote pain and inflammation.
With less cyclooxygenases, less prostaglandins.

The difference is it actually fucking works, unlike other OTC painkillers like Tylenol (acetaminophen) or Aleve (naproxen).
Seriously, 400-600 mg (two-three Advils, its brand name) will euthanize a headache.
Not sure how it works for muscle/joint aches, but holy fuck, is it good for headaches.
Fuck Tylenol, that shit harms your liver.
Not sure how good Aleve works, but it probably sucks.

It is worth noting that all NSAIDs except aspirin have issues with raising blood pressure and harming the heart with chronic use, as well as digestive tract problems. This includes ibuprofen.

Also, you can make a topical medicine out of ibuprofen gel capsules.
Use only one capsule at a time until you find out the right strength.

Take one GEL CAPSULE of ibuprofen.
Break it with a thumbtack, small-pointed knife, or pair of scissors.
Pop the contents into one cup, then take some lotion.
Mix it with one kitchen spoon of the lotion.
Add 3-4 drops of orange oil to increase absorption through skin.

My migraines acted up, but the pharmacy didn't get my prescription in time, so I just picked up some ibuprofen.
by jacrispy vulcano is my mom January 19, 2018
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An orally taken, general, non-opiate, painkiller commonly sold as Advil. Common dosage is 200mg. Often referred to as <Vitamin I>.
I had a killer headache so i took two ibuprofen.
by Jesse Hertz December 20, 2006
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Code word to be used for “sex.”
Man: “I need some ibuprofen...”
Woman: “I’ve got some in my apartment...”
by BenStumpin June 21, 2019
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A painkiller, usually used in a sentence when someone has a serious migraine or is seriously pissed off.
Person 1: *talks obnoxiously about some random bullshit*
Person 2: If you don't shut up, I'm going to have to take some high doses of ibuprofen .
by Fuckoffemilie November 2, 2018
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1 A strong painkiller, unlike others in that it works.

2 Good drugs
by SomethingElse June 16, 2003
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very sexual. spicy girls in an anime show luring a yard worker into a lounge for some lemonaide. the sweaty mans nose stars to bleed bc the asian girl offer him some mexican ibuprofen which gets him going.
i'm gonna mexican ibuprofen your chihuahua.
by rawrxdlover June 24, 2017
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