(exp.) 1. A phrase, originating in New York, used as a combination greeting, response to itself, question of welfare, response to FOGEDDABODDIT!, and response to YOU TALKIN' TA ME?.
"'ey. How YOU doin'?" "How YOU doin'?" "FOGEDDABODDIT!"
by Razukin December 2, 2002
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A popular phrase coined by radio DJ and tv personality, Wendy Williams. How You Doin?! is not only a greeting of the show, but when something or someone is very gay.
Jordan *Very feminine and flamboyant*: Hey miss honey, what's goin on sweetness?!

Kalisha: How you doin?!?!
by Tyrell Jenkins October 15, 2006
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A bastardization of the greeting "How are you doing?" Used by the stereotypical mobster in popular culture. Heard in countless movies, TV shows, commercials, etc. Most often used in real life by actual mobsters, Americans of Italian descent living in New York or New Jersey (and elsewhere), or retards who want to sound tough.
Tony Soprano: (to his crew as he walks into the Bada Bing!) "How you doin'?"
by Joey Baggadonuts July 28, 2006
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It's like whats up. For cool people. Used frequently by hipters and those who wish they were. Generally used among good friends, it's not for everyone.
A: Hey Ben, how you ball?

B: Pretty hard bah
by G-Mart El Fresh April 18, 2012
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1. Short for "How are you doing?" It can also be used for the pickup variety of that question, "How you doin'? ;-)"

2. Also short for "How did you do?"
(1)
Guy: How you do? Baby.
Girl: OMG, where did you learn how to speak? That's your pickup line? hahahaha

(2)
You: How you do?
Guy: I used the line that you told me, but she laughed at me. That was so messed up.
by w3source February 12, 2008
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