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A misspelling of guido, which is a pejorative term applied to certain Italian-American males.
Guy 1: Joey Spagnola? He's a total gweedo.

Guy 2: Dude, it's spelled "guido".

Guy 1: Oh.
gweedo by joeySP January 10, 2009
Related Words
A wigger that dresses like one of the Sopranos.
"Who's that guy in the track-suit with the greasy hair?"
"Some fuckin' gweedo!"
"Someone should tell 'em to lay off the cologne."
gweedo by twobitp December 29, 2006
the act of two people putting their buttholes together while having sexual intercourse and droppin a steamy pickle (Shit) in eachothers bung holes.
I was watching Full House all day and Bob Saget gave me the urge to have a sloppy gweedo session with my girlfriend.
gweedo by Ignacio Dumpington February 21, 2009
A slight mustache that looks horrible but the person who has it is extremely proud of it. It is made of peach fuzz and is just hairy enough to look disgusting.
Phil's gweedo stache made me want to throw up.
Gweedo by Pierre von Stoiben October 7, 2005
A Gweedo/Gweedette is a hardcore marijuana smoker from Denver, Colorado and/or other Areas. They are fans of local Denver rap group Chapter Black. They're often seen wearing orange clothes and bandanas.
Robert: "Whats goin' down GWEEDOS?, Lets go smoke some marijuana behind the church!"

Group of Gweedos: "Hell yeah!"
Gweedo by Denver Native January 7, 2010
Loser guys with bad hair and clothes.
Gweedos are underweight guys with really bad hair such as mullets or any other type of hair that makes you think wtf. They are usually seen wearing too tight, too faded, tapered jeans, tucked in with a t-shirt with the name of a beer on it. They are often times spoted with their class jackets, from 1988.
Gweedo by Amber8888 September 21, 2005