1. A polite and well meaning colloquialism used to express agreement with a cohort. (This phrase entered american vernacular when famed celebrity/artist/rapper/pornographer/movie star Snoop Dogg started using it and other words containing the suffix "izzle" or "izzy.")

2. To aquiesce to or agree with a proposition or idea offered by an affable peer.
My Boy D-Bo axed me if I was going to the game tonight... I said "Fo' Shizzle my nizzle" in the pitch of a tenor.
by Barry February 12, 2004
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Fo shizzle my nizzle translates to For sure my nigger, which translates to "Ok" in white language.
Steve: Hey you wanna go grab some KFC?
Marquis: Fo shizzle my nizzle!
Steve: I'm no nigger!
by Adam! At The Disco December 21, 2005
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Meaning:
1. affirmative; For sure, ma nigga

not necessarily in any racial context.
From a branch of urban (American) slang which adds 'izz' or varients of (ie izzle/izzo) to words to create a more rhyme like 'melody' to sentences.
kid 1: "It's late, I'm heading back to the hizzous... you stayin?"

kid 2: "fo' shizzle my nizzle"
by theJudge August 9, 2003
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slang for "for sure my n*****"
Tyler: do you wanna go to the movies tonight?

Lydian: fo shizzle my nizzle
by Lydian Beck April 9, 2008
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fo shizzle my nizzle translates into "I will definitely acquiesce indubitably in the said activity such as drinking cool aid, grape soda, orange soda, KFC, watermelon, waffles, and various other food items".
Boo: Yo, would you like to participate in the consumption of Kentucky Fried Chicken, while consuming a 40 oz alcoholic beverage in the back of my vehicle that has the bass so far up that whenever I commute near a seismographic station, there seems to be a 10.7 on the Richter scale in Ethiopia.
La Fawnda: Fo shizzle my nizzle.
Boo: Well, that sounds swell to me. Let us hop in and endear in the lovemaking in the opposite sex.
by kevk77 March 15, 2009
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