"She looks so derpy with that duck face!"
"That guy looks so derpy in his pictures."
by lilstrudel February 28, 2012
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To be inefficient, slow, unable, inexperienced, not working correctly, stupid, naive, etc. A word that usually takes the place of "retarded."

Can be pertaining to a person or a thing.
I tried to send my essay in via email last night, but my computer was being derpy.

*Friend trips and falls over own feet
You are so derpy sometimes
by Derpyhoovs July 27, 2011
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When your crabs have herpes.
Oh man that dude has a horrid case of derpies.
by LIONwho March 29, 2011
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Uncontrollably horny female with a hunger for dick, ready to take it in any hole at anytime.
Did you see that girl brought a 12 pack of condoms with her to the party? "Yea she's real derpy"
by Terez Slowens October 7, 2015
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Derpy - a homicidal rapist usually hailing from Hawaii, often with the intentions of slicing off people's penises and jellifying them for their scorpion overlords.
Baron Von Muffington is such a Derpy!
by Boss Nigger. March 21, 2012
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Something that can explain something that is cool or dumb.
1)Man this song is so derpy!
2)Yah, that guy is such a derpy derp!
by Rob June 18, 2004
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A universal nickname for that really annoying girl that everyone hates. She could be your clingy ex-girlfriend or the girl in your government class that always asks stupid questions. If she's "Derpy" then chances are that everyone you know can find something they hate about her.
"Dude, derpy showed up at my house yesterday, she's so creepy!"

"Are you talking about that blonde chick with the annoying voice? I hate that chick, she gets on my nerves."
by thedirtydan May 17, 2013
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