4
cocain, blow, snort, butta, candy.
"I bought some derns in the club and it made me shit my pants."
by dms123 August 09, 2005
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5
A Dude so insanely, disgustingly ugly that if anyone ever witnessed their ugliness, they would turn to gouging their eyes out and hoping for a quick death to eliminate the memory of said face.
by Thatdude4554 November 29, 2015
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7
A harsher method of referring to someone (or something) that frequently exhibits characteristics commonly seen as extremely "drenny," also referred to as "extremely nerdy" or any extreme adjectives of a similar nature. Dren is commonly used as a less abrasive variation.

Note: Dern came into use by means of a misspelling of the original phrase, "dern." Since then it has become a harsher word and should be used only when circumstances do in fact warrant it.
"The name's Bond. Covalent Bond."
"You are such a dern!"
by Franny D February 27, 2009
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