Camel Knuckle Share definition Flag A rather large nut sack protruding through the contours of someone's pants.(usually polyester pants) Whoa! That guy in the leisure suit has a serious camel knuckle going on. Camel Knuckle by testiclese1 March 17, 2007 0 0 Get merch Get the Camel Knuckle mug. Buy Now — $32.95 See more merch