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Means high quality drugs:

Pure Columbian heroin
Crack-Cocaine ("rocks")
Quote from hit tv show "Chappelle's Show":

Tyrone Buggums at the class talking with little kids:

"You can't fly on drugs, only on the "best stuff". But you can't get the "best stuff", I don't!"
by BabyBoss October 28, 2009
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