Ur sister mister is the next level of ur granny tranny. It is stronger than ur mom gay, ur dad lesbian and ur granny tranny combined. Nobody who ever heard this sentence is alive.
John: Hey Jeff ur mom gay
Jeff: No u
John: Ur dad lesbian
Jeff: Ur granny tranny
John: Ur sister mister
Jeff: *jeff and his whole family instantly die and go to the deepest layer of hell*
by TheRealMemeGod March 14, 2018
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The ultimate weapon to use on anyone. This is 100 times worse than "ur mom gay", "ur dad lesbian", and ur granny tranny". Everytime this is used a planet explodes.
Mark: ur entire family lesbian
Patrick: ur sister a mister
Mark: *gets removed from reality*
by pikminfreak26 March 13, 2018
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The absolute killer of 'ur mom gay' 'ur dad lesbian' 'ur granny a tranny' and 'your grandpap a trap'.
Henry: Don't make do it.
Joe: Do it pussy.
Henry: Ur grandpap a trap.
Joe: Bitch please.
Joe: Ur sister a mister.
*Henry's body turns into dust*
by LoCaboose March 13, 2018
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The worse possible insult above "ur mom gay" "ur dad lesbian" "ur granny a tranny" and "ur granpap a trap"
James: lol ur mom gay
Holden: ur dad lesbian
James: ur granny a tranny
Holden: ur granpap a trap
James: well ur sister a mister
Holden: *shrivels up and dies*
by Stakeynya March 19, 2018
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An insult known and feared by all of mankind and even god himself... An insult so powerful and so great it could destroy life as we know it. One of the only insults more powerful than ur mom gae

Below we shall see but mortal a man attempt to use this insult against another though be warned life... may go extinct
john: Hey mike!
Mike: yeah what is it John?
John: ur mom gae
Mike: pathetic!
also mike: UR DAD LESBIAN!
John: ur brother a mother
Mike: you have forced me to use my ultimate power...
john: NO! MIKE DONT DO IT!!!!!
Mike: ur sister A Mister
(the solar system gets torn into pieces and life as we know it dies)

NOW BUT ONE MAN STANDS AND HIS NAME SHALL FOREVER BE FEARED AND WORSHIPPED!!!! A MAN SO POWERFUL GOD HIMSELF PISSED HIMSELF.
by tuu0prartf April 30, 2019
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If the "Your Granny and TRANNY!" get pulled out you must say "YOUR SISTER A MISTER!!" and this rude human will die of brain cancer.
Tim"You are a cunt"
Me"No you"
Tim"Ur dad has big gay"
Me"No u"
Tim"Your granny tranny"
Me"Your sister a mister"
Tim *DIES*
by Gayuun March 14, 2018
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Even worse than ur mom gay, ur dad lesbian and ur granny tranny! Makes Jupiter explode!
Pete: Ur granny tranny
Alex: Ur sisters a mister
Jupiter *explodes*
by JrgnVS March 14, 2018
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