1 definition by TheRealMemeGod

Ur sister mister is the next level of ur granny tranny. It is stronger than ur mom gay, ur dad lesbian and ur granny tranny combined. Nobody who ever heard this sentence is alive.
John: Hey Jeff ur mom gay
Jeff: No u
John: Ur dad lesbian
Jeff: Ur granny tranny
John: Ur sister mister
Jeff: *jeff and his whole family instantly die and go to the deepest layer of hell*
by TheRealMemeGod March 14, 2018
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