Deceptively nearby, especially when referring to a destination requiring a car trip. The term applies well in areas where roads are winding and possess very few landmarks, such as in rural communities.
The county courthouse is right up the road. (In reality, it takes about 45 minutes to get there.)
When someone cuts themselves with a razor up the arm, along a vein, instead of "across the street" which means going across your wrist. Up the road is much more painful, but faster.