1)When somebody under the influence of any drug begins to become very anctious, or nervous.
2)The act of freaking out
Dude, quit fuckin tweakin out...fuckin tweaker
by DayDay October 21, 2004
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Stimulant induced fixation on an activity/project...

usually an instance wherein the person feels overwhelmingly compelled to take on a mentally stimulating task, even perhaps over do it
without regard for the amount of time spent

This project or activity can often be meaningless/ unimportant but nonetheless irristable

aka "being stuck," "geeking," "tweeking"
"A meth user can stay awake for several days at a time, and is often content to perform repetitive tasks -- even having the patience to stitch together shredded documents"-newspaper article

OBSESSIVELY tweak out on :
rearranging sock drawers; organizing and rearranging; disassembling electronics and appliances; drawing; cleaning; carpet surfing ( crawling around on the floor searching for crumbs of drugs ); picking one's own face; being unable to stop staring at the monitor to their outside surveillance camera; over analyzing an incident, event, topic of discussion, comment, or idea; conspiring; Captain Curtains aka Window Policing ( peeking out the windows every few seconds )
by Nargle the Garthon GAK GAK GAK January 11, 2006
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A common Evanstonian (citizen of Evanston, IL) word

1. a. In a state somewhat equivalent to a bad high; when the mind interprets things in the physical realm differently from what they really are (commonly location based)

b. Somewhat similar to trip, but in a more negative way

2. When the mind freaks out similarly to an excited panic attack

3. To be in a state of high excitement
1. "Holy shit man! I think the walls are trying to kill me! I'm tweaking out man!"

2. "Whoa, I thought that cat jumped at me, I saw it outta the corner of my eye!"
"Naw man, you're just tweaking out."

3. "Oh shit man, what are we gonna do? I just shot a cop! What are we gonna do? I'm tweaking out man, I'm tweaking out!!"
by Spectre13 March 30, 2009
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A person typically and habitually under the influence of cocaine, methamphetamine, diacetylmorphine, and any other tweaker choice you could think of.
Bob: Hey Jimmy see that guy over there?
Jimmy: Yeah man, he's acting pretty weird.

Bob: Eh, must be tweaked out or something .
Jimmy: On the real lets keep movin.
by Burberry Hilfiger November 12, 2015
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To become very upset, worried, flip out or freak out.
My mom tweaked out when she heard about me and Kaleb.
by Ami December 18, 2002
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A person doing lots of meth in a short period of time. Also known as a tweaker.
Guy 1: man Johns really tweaked out.
Guy 2: yeah I know. Hes a tweaker.
by PinkPanada January 15, 2016
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